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Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6. Briefly, to construct an isobologram and determine the type of interaction between drugs, the prerequisite is to know the potency and a form of dose-effect curve of each drug alone. Animals were observed daily for survival and any reactions to treatment. Portugal Portuguese /webroot/web/pdf/WWMSDS/CMD/PT/P_PT_62866. Over the counter creams with ketoconazole oral tablet doesn’t cause drowsiness but it can cause other side effects.
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